Correlation of TIMP1-MMP2/MMP9 Gene Expression Axis Changes with Treatment Efficacy and Survival of NSCLC Patients

In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in microenvironment, including extracellular matrix (ECM), which is not only a scaffold for cells, but also reservoir cytokines, chemokines growth factors. Metalloproteinases (MMPs) among elements that enable ECM remodeling. The publication focuses on problem gene expression MMP2, MMP9 tissue inhibitor metalloproteinases (TIMP1) blood NSCLC patients during therapy (one year after surgical resection tumor). paper analyzes differences studied genes tumor tissue, as well data collected publicly available databases. results tests showed no tested therapy; however, were observed was characterized by higher MMP2 MMP9, compared to non-cancerous unchanged TIMP1. Nevertheless, each associated with shorter patient survival. Interestingly, it increased metalloproteinase genes, unfavorable patients.